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Originally published as Genetics Published Articles Ahead of Print on June 4, 2006.
Genetics, Vol. 173, 2407-2410, August 2006, Copyright © 2006
doi:10.1534/genetics.106.060749
Deletion Polymorphism of Disc1 Is Common to All 129 Mouse Substrains: Implications for Gene-Targeting Studies of Brain Function
Steven J. Clapcote*,1 and
John C. Roder*,
* Mount Sinai Hospital Research Institute, Toronto, Ontario M5G 1X5, Canada and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
1 Corresponding author: Room 860, Mount Sinai Hospital Research Institute, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
E-mail: clapcote{at}mshri.on.ca
We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.
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