Originally published as Genetics Published Articles Ahead of Print on May 15, 2006.

Genetics, Vol. 173, 2403-2406, August 2006, Copyright © 2006
doi:10.1534/genetics.106.059253

Loss-Of-Function Alleles of the JIL-1 Kinase Are Strong Suppressors of Position Effect Variegation of the wm4 Allele in Drosophila

Stephanie Lerach, Weiguo Zhang, Xiaomin Bao, Huai Deng, Jack Girton, Jørgen Johansen and Kristen M. Johansen1

Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011

1 Corresponding author: Department of Biochemistry, Biophysics, and Molecular Biology, 3154 Molecular Biology Building, Iowa State University, Ames, IA 50011. 
E-mail: kristen{at}iastate.edu

In this article we show that hypomorphic loss-of-function alleles of the JIL-1 histone H3S10 kinase are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL-1 activity can counteract the effect of the dominant enhancer E(var)2-1 on PEV.




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