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Originally published as Genetics Published Articles Ahead of Print on June 18, 2006.
Genetics, Vol. 173, 2021-2031, August 2006, Copyright © 2006
doi:10.1534/genetics.106.058651
Patterns of Nucleotide Polymorphism Distinguish Temperate and Tropical Wild Isolates of Caenorhabditis briggsae
Asher D. Cutter*,1,
Marie-Anne Félix
,
Antoine Barrière and
Deborah Charlesworth*
* Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom and Institut Jacques Monod, Centre National de la Recherche Scientifique, Universities Paris 6/7, Paris, France
1 Corresponding author: Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.
E-mail: acutter{at}eeb.utoronto.ca
Caenorhabditis briggsae provides a natural comparison species for the model nematode C. elegans, given their similar morphology, life history, and hermaphroditic mode of reproduction. Despite C. briggsae boasting a published genome sequence and establishing Caenorhabditis as a model genus for genetics and development, little is known about genetic variation across the geographic range of this species. In this study, we greatly expand the collection of natural isolates and characterize patterns of nucleotide variation for six loci in 63 strains from three continents. The pattern of polymorphisms reveals differentiation between C. briggsae strains found in temperate localities in the northern hemisphere from those sampled near the Tropic of Cancer, with diversity within the tropical region comparable to what is found for C. elegans in Europe. As in C. elegans, linkage disequilibrium is pervasive, although recombination is evident among some variant sites, indicating that outcrossing has occurred at a low rate in the history of the sample. In contrast to C. elegans, temperate regions harbor extremely little variation, perhaps reflecting colonization and recent expansion of C. briggsae into northern latitudes. We discuss these findings in relation to their implications for selection, demographic history, and the persistence of self-fertilization.
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