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Originally published as Genetics Published Articles Ahead of Print on April 19, 2006.
Genetics, Vol. 173, 1813-1816, July 2006, Copyright © 2006
doi:10.1534/genetics.106.057927
Mapping Novel Traits by Array-Assisted Bulk Segregant Analysis in Saccharomyces cerevisiae
Matthew J. Brauer*,
,
Cheryl M. Christianson,
Dave A. Pai and
Maitreya J. Dunham,1
* Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544
1 Corresponding author: 120 Carl Icahn Lab, Lewis-Sigler Institute, Princeton University, Princeton, NJ 08544.
E-mail: maitreya{at}princeton.edu
We demonstrate a new method, microarray-assisted bulk segregant analysis, for mapping traits in yeast by genotyping pooled segregants. We apply a probabilistic model to the progeny of a single cross and as little as two microarray hybridizations to reliably map an auxotrophic marker, a Mendelian trait, and a major-effect quantitative trait locus.
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