- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Data Supplement
-
All Versions of this Article:
genetics.106.057455v1
173/2/943 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Ghazalpour, A.
- Articles by Mehrabian, M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Ghazalpour, A.
- Articles by Mehrabian, M.
Originally published as Genetics Published Articles Ahead of Print on April 19, 2006.
Genetics, Vol. 173, 943-951, June 2006, Copyright © 2006
doi:10.1534/genetics.106.057455
Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice
Anatole Ghazalpour*,
Xuping Wang
,
Aldons J. Lusis*,,
,
and
Margarete Mehrabian,1
Department of Human Genetics, Department of Medicine and * Department of Microbiology Immunology and Molecular Genetics and Molecular Biology Institute, University of California, Los Angeles, California 90095-1679
1 Corresponding author: David Geffin School of Medicine at UCLA, Department of Medicine/Cardiology, 3-220 MRL, Charles Young Dr., Los Angeles, CA 90095-1679.
We previously mapped a locus on chromosome 6 with a large effect (LOD > 6) on aortic lesion size in a (C57BL/6J x CAST/Ei) F2 cross and identified arachidonate 5-lipoxygenase (5LO) as a candidate gene in this region. Subsequent studies with the 5LO knockout model showed effects on atherosclerosis and aortic aneurysms. We now report detailed genetic analysis of the chromosome 6 locus. We created a panel of overlapping and reciprocal subcongenic lines from the B6.CAST Ldlr–/– chromosome 6 congenic strain (CON6.Ldlr–/–) and analyzed aortic lesion size in different subcongenic lines. Our results revealed that there are at least two subregions, designated as Ath37 and Ath38 that affect the size of aortic lesions independently of 5LO. We also showed that homozygote 5LO null mice develop smaller atherosclerotic lesions. We conclude that the relation between the mouse chromosome 6 locus and atherosclerosis is complex and is due to at least two genes with large effects within this region. This complexity should be considered when interpreting results of knockout studies.
This article has been cited by other articles:
 |
|
 |
|
  S. Chiu, K. Kim, K. A. Haus, G. M. Espinal, L. V. Millon, and C. H. Warden Identification of positional candidate genes for body weight and adiposity in subcongenic mice Physiol Genomics, September 11, 2007; 31(1): 75 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Meng, I. Vera, N. Che, X. Wang, S. S. Wang, L. Ingram-Drake, E. E. Schadt, T. A. Drake, and A. J. Lusis Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics PNAS, March 13, 2007; 104(11): 4530 - 4535. [Abstract] [Full Text] [PDF]
|
|