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Originally published as Genetics Published Articles Ahead of Print on April 19, 2006.
Genetics, Vol. 173, 709-726, June 2006, Copyright © 2006
doi:10.1534/genetics.106.056465
Identification and Classification of Genes That Act Antagonistically to let-60 Ras Signaling in Caenorhabditis elegans Vulval Development
Craig J. Ceol1, Frank Stegmeier2, Melissa M. Harrison and H. Robert Horvitz3
Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
3 Corresponding author: Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Ave., Room 68-425, Cambridge, MA 02139.
E-mail: horvitz{at}mit.edu
The synthetic multivulva (synMuv) genes negatively regulate Ras-mediated vulval induction in the nematode Caenorhabditis elegans. The synMuv genes define three classes, A, B, and C, such that double mutants carrying mutations in genes of any two classes are multivulva. The class B synMuv genes include lin-35, a homolog of the retinoblastoma (Rb) tumor suppressor gene, as well as homologs of genes that function with Rb in transcriptional regulation. We screened for additional synMuv mutations using a strategy different from that of previous synMuv genetic screens. Some of the mutations we recovered affect new synMuv genes. We present criteria for assigning synMuv mutations into different genetic classes. We also describe the molecular characterization of the class B synMuv gene lin-65.
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