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Originally published as Genetics Published Articles Ahead of Print on April 2, 2006.
Genetics, Vol. 173, 579-587, June 2006, Copyright © 2006
doi:10.1534/genetics.105.050195
Histone H1 of Saccharomyces cerevisiae Inhibits Transcriptional Silencing
Marie Veron*,
Yanfei Zou
,
Qun Yu,
Xin Bi,
Abdelkader Selmi*,
Eric Gilson
and
Pierre-Antoine Defossez*,1
* Section Recherche, Institut Curie, CNRS UMR218, Paris, 75248, France, Department of Biology, University of Rochester, Rochester, New York 14627-0211 and Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Supérieure de Lyon, CNRS UMR5161, IFR 128, Lyon 69364, France
1 Corresponding author: Institut Curie, CNRS UMR218, 26 rue d'Ulm, Paris, 75248, France.
E-mail: defossez{at}curie.fr
Eukaryotic genomes contain euchromatic regions, which are transcriptionally active, and heterochromatic regions, which are repressed. These domains are separated by "barrier elements": DNA sequences that protect euchromatic regions from encroachment by neighboring heterochromatin. To identify proteins that play a role in the function of barrier elements we have carried out a screen in S. cerevisiae. We recovered the gene HHO1, which encodes the yeast ortholog of histone H1, as a high-copy modifier of barrier activity. Histone H1 is a linker histone that binds the outside of nucleosomes and modifies chromatin dynamics. Here we show that Hho1p reinforces the action of several types of barrier elements, and also inhibits silencing on its own.
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  Q. Yu, H. Kuzmiak, Y. Zou, L. Olsen, P.-A. Defossez, and X. Bi Saccharomyces cerevisiae Linker Histone Hho1p Functionally Interacts with Core Histone H4 and Negatively Regulates the Establishment of Transcriptionally Silent Chromatin J. Biol. Chem., January 9, 2009; 284(2): 740 - 750. [Abstract] [Full Text] [PDF]
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