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Originally published as Genetics Published Articles Ahead of Print on April 2, 2006.
Genetics, Vol. 173, 1169-1173, June 2006, Copyright © 2006
doi:10.1534/genetics.106.058420
Telomeric Silencing of an Open Reading Frame in Saccharomyces cerevisiae
Arnold B. Barton and David B. Kaback1
Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ–New Jersey Medical School, Graduate School of Biomedical Sciences, Newark, New Jersey 07103
1 Corresponding author: Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ–New Jersey Medical School, 225 Warren St., P.O. Box 1709, Newark, NJ 07101-1709.
E-mail: kaback{at}umdnj.edu
The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IMD1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.
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