help button home button Genetics J Virology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on October 3, 2005.

Genetics, Vol. 173, 419-434, May 2006, Copyright © 2006
doi:10.1534/genetics.105.047985

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
genetics.105.047985v1
173/1/419    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kirkpatrick, M.
Right arrow Articles by Barton, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kirkpatrick, M.
Right arrow Articles by Barton, N.

Chromosome Inversions, Local Adaptation and Speciation

Mark Kirkpatrick*,1 and Nick Barton{dagger}

* Section of Integrative Biology, University of Texas, Austin, Texas 78712 and {dagger} Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland

1 Corresponding author: Section of Integrative Biology, 1 University Station C-0930, Austin, TX 78712.
E-mail: kirkp{at}mail.utexas.edu

We study the evolution of inversions that capture locally adapted alleles when two populations are exchanging migrants or hybridizing. By suppressing recombination between the loci, a new inversion can spread. Neither drift nor coadaptation between the alleles (epistasis) is needed, so this local adaptation mechanism may apply to a broader range of genetic and demographic situations than alternative hypotheses that have been widely discussed. The mechanism can explain many features observed in inversion systems. It will drive an inversion to high frequency if there is no countervailing force, which could explain fixed differences observed between populations and species. An inversion can be stabilized at an intermediate frequency if it also happens to capture one or more deleterious recessive mutations, which could explain polymorphisms that are common in some species. This polymorphism can cycle in frequency with the changing selective advantage of the locally favored alleles. The mechanism can establish underdominant inversions that decrease heterokaryotype fitness by several percent if the cause of fitness loss is structural, while if the cause is genic there is no limit to the strength of underdominance that can result. The mechanism is expected to cause loci responsible for adaptive species-specific differences to map to inversions, as seen in recent QTL studies. We discuss data that support the hypothesis, review other mechanisms for inversion evolution, and suggest possible tests.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
N. C. Manoukis, J. R. Powell, M. B. Toure, A. Sacko, F. E. Edillo, M. B. Coulibaly, S. F. Traore, C. E. Taylor, and N. J. Besansky
A test of the chromosomal theory of ecotypic speciation in Anopheles gambiae
PNAS, February 26, 2008; 105(8): 2940 - 2945.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. A. F. Noor, D. A. Garfield, S. W. Schaeffer, and C. A. Machado
Divergence Between the Drosophila pseudoobscura and D. persimilis Genome Sequences in Relation to Chromosomal Inversions
Genetics, November 1, 2007; 177(3): 1417 - 1428.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. L. Evans, P. A. Mena, and B. F. McAllister
Positive Selection Near an Inversion Breakpoint on the Neo-X Chromosome of Drosophila americana
Genetics, November 1, 2007; 177(3): 1303 - 1319.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
W. J. Kennington, A. A. Hoffmann, and L. Partridge
Mapping Regions Within Cosmopolitan Inversion In(3R)Payne Associated With Natural Variation in Body Size in Drosophila melanogaster
Genetics, September 1, 2007; 177(1): 549 - 556.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. H. Rieseberg and J. H. Willis
Plant Speciation
Science, August 17, 2007; 317(5840): 910 - 914.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. M. Graze, O. Barmina, D. Tufts, E. Naderi, K. L. Harmon, M. Persianinova, and S. V. Nuzhdin
New Candidate Genes for Sex-Comb Divergence Between Drosophila mauritiana and Drosophila simulans
Genetics, August 1, 2007; 176(4): 2561 - 2576.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. S. Chang and M. A. F. Noor
The Genetics of Hybrid Male Sterility Between the Allopatric Species Pair Drosophila persimilis and D. pseudoobscura bogotana: Dominant Sterility Alleles in Collinear Autosomal Regions
Genetics, May 1, 2007; 176(1): 343 - 349.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. A. Machado, T. S. Haselkorn, and M. A. F. Noor
Evaluation of the Genomic Extent of Effects of Fixed Inversion Differences on Intraspecific Variation and Interspecific Gene Flow in Drosophila pseudoobscura and D. persimilis
Genetics, March 1, 2007; 175(3): 1289 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. M. Marshall and R. E. Weiss
A Bayesian Heterogeneous Analysis of Variance Approach to Inferring Recent Selective Sweeps
Genetics, August 1, 2006; 173(4): 2357 - 2370.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Vasemagi
The Adaptive Hypothesis of Clinal Variation Revisited: Single-Locus Clines as a Result of Spatially Restricted Gene Flow
Genetics, August 1, 2006; 173(4): 2411 - 2414.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Genetics Society of America.