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Originally published as Genetics Published Articles Ahead of Print on March 17, 2006.
Genetics, Vol. 173, 267-277, May 2006, Copyright © 2006
doi:10.1534/genetics.106.056200
Increase of the Spontaneous Mutation Rate in a Long-Term Experiment With Drosophila melanogaster
Victoria Ávila, David Chavarrías, Enrique Sánchez, Antonio Manrique, Carlos López-Fanjul and Aurora García-Dorado1
Departamento de Genética, Facultad de Biología, Universidad Complutense, 28040 Madrid, Spain
1 Corresponding author: Departamento de Genética, Facultad de Biología, Universidad Complutense, 28040 Madrid, Spain.
E-mail: augardo{at}bio.ucm.es
In a previous experiment, the effect of 255 generations of mutation accumulation (MA) on the second chromosome viability of Drosophila melanogaster was studied using 200 full-sib MA1 lines and a large C1 control, both derived from a genetically homogeneous base population. At generation 265, one of those MA1 lines was expanded to start 150 new full-sib MA2 lines and a new C2 large control. After 46 generations, the rate of decline in mean viability in MA2 was 
2.5 times that estimated in MA1, while the average degree of dominance of mutations was small and nonsignificant by generation 40 and moderate by generation 80. In parallel, the inbreeding depression rate for viability and the amount of additive variance for two bristle traits in C2 were 2–3 times larger than those in C1. The results are consistent with a mutation rate in the line from which MA2 and C2 were derived about 2.5 times larger than that in MA1. The mean viability of C2 remained roughly similar to that of C1, but the rate of MA2 line extinction increased progressively, leading to mutational collapse, which can be ascribed to accelerated mutation and/or synergy after important deleterious accumulation.
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