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Originally published as Genetics Published Articles Ahead of Print on February 1, 2006.

Genetics, Vol. 172, 2683-2688, April 2006, Copyright © 2006
doi:10.1534/genetics.105.051029

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Saccharomyces cerevisiae Polymerase {zeta} Functions in Mitochondria

Hengshan Zhang*, Aditi Chatterjee{dagger} and Keshav K. Singh1

* Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263 and {dagger} Johns Hopkins Oncology Center, Baltimore, Maryland 21231-1000

1 Corresponding author: Department of Cancer Genetics, Cell and Virus Bldg., Room 247, Roswell Park Cancer Institute, Elm and Carlton Sts., Buffalo, NY 14263.
E-mail: keshav.singh{at}roswellpark.org

The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase {zeta} and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase {zeta} and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase {zeta} and Rev1 proteins function in the mitochondria.






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Copyright © 2006 by the Genetics Society of America.