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Originally published as Genetics Published Articles Ahead of Print on February 1, 2006.
Genetics, Vol. 172, 2683-2688, April 2006, Copyright © 2006
doi:10.1534/genetics.105.051029
Saccharomyces cerevisiae Polymerase 
Functions in Mitochondria
Hengshan Zhang*,
Aditi Chatterjee
and
Keshav K. Singh1
* Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263 and Johns Hopkins Oncology Center, Baltimore, Maryland 21231-1000
1 Corresponding author: Department of Cancer Genetics, Cell and Virus Bldg., Room 247, Roswell Park Cancer Institute, Elm and Carlton Sts., Buffalo, NY 14263.
E-mail: keshav.singh{at}roswellpark.org
The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase 
and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase and Rev1 proteins function in the mitochondria.
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