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Originally published as Genetics Published Articles Ahead of Print on December 30, 2005.
Genetics, Vol. 172, 2011-2014, March 2006, Copyright © 2006
doi:10.1534/genetics.105.052183
Positive Selection Can Create False Hotspots of Recombination
Floyd A. Reed1 and Sarah A. Tishkoff
Department of Biology, University of Maryland, College Park, Maryland 20742
1 Corresponding author: 4231 Biology, Department of Biology, University of Maryland, College Park, MD 20742.
E-mail: freed{at}umd.edu
Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.
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