- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.105.048520v1
172/3/1595 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Leips, J.
- Articles by Mackay, T. F. C.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Leips, J.
- Articles by Mackay, T. F. C.
Originally published as Genetics Published Articles Ahead of Print on November 4, 2005.
Genetics, Vol. 172, 1595-1605, March 2006, Copyright © 2006
doi:10.1534/genetics.105.048520
Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster
Jeff Leips*,
,1,
Paul Gilligan and
Trudy F. C. Mackay
* Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 and Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695
1 Corresponding author: Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250.
E-mail: leips{at}umbc.edu
Life-history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic contribution to variation in fitness components, we know very little about the underlying genetic architecture of such changes. We used a set of recombinant inbred lines to map and characterize the effects of quantitative trait loci (QTL) affecting fecundity of Drosophila melanogaster females at 1 and 4 weeks of age. We identified one QTL on the second chromosome and one or two QTL affecting fecundity on the third chromosome, but these QTL affected fecundity only at 1 week of age. There was more genetic variation for fecundity at 4 weeks of age than at 1 week of age and there was no genetic correlation between early and late-age fecundity. These results suggest that different loci contribute to the variation in fecundity as the organism ages. Our data provide support for the mutation accumulation theory of aging as applied to reproductive senescence. Comparing the results from this study with our previous work on life-span QTL, we also find evidence that antagonistic pleiotropy may contribute to the genetic basis of senescence in these lines as well.
This article has been cited by other articles:
 |
|
 |
|
  J. A. Moorad and D. E.L. Promislow What can genetic variation tell us about the evolution of senescence? Proc R Soc B, June 22, 2009; 276(1665): 2271 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hoikkala, M. Saarikettu, J. S. Kotiaho, and J. O. Liimatainen Age-related decrease in male reproductive success and song quality in Drosophila montana Behav. Ecol., January 1, 2008; 19(1): 94 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-S. Kim, B. A. Logsdon, S. Park, J. G. Mezey, and K. Lee Quantitative Trait Loci for the Circadian Clock in Neurospora crassa Genetics, December 1, 2007; 177(4): 2335 - 2347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Reynolds, S. Temiyasathit, M. M. Reedy, E. A. Ruedi, J. M. Drnevich, J. Leips, and K. A. Hughes Age Specificity of Inbreeding Load in Drosophila melanogaster and Implications For the Evolution of Late-Life Mortality Plateaus Genetics, September 1, 2007; 177(1): 587 - 595. [Abstract] [Full Text] [PDF]
|
|