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Originally published as Genetics Published Articles Ahead of Print on December 1, 2005.

Genetics, Vol. 172, 1369-1372, February 2006, Copyright © 2006
doi:10.1534/genetics.105.046110

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The Saccharomyces cerevisiae Phosphatase Activator RRD1 Is Required to Modulate Gene Expression in Response to Rapamycin Exposure

Julie Douville*, Jocelyn David*, Karine M. Lemieux{dagger}, Luc Gaudreau{dagger} and Dindial Ramotar*,1

{dagger} Département de Biologie, Université de Sherbrooke, Sherbrooke, Quebec J1K 2R1, Canada and the * University of Montreal, Maisonneuve-Rosemont Hospital, Guy-Bernier Research Centre, Montreal, Quebec H1T 2M4, Canada

1 Corresponding author: University of Montreal, Maisonneuve-Rosemont Hospital, Guy-Bernier Research Centre, 5415 de l'Assomption, Montreal, Quebec H1T 2M4, Canada.
E-mail: dramotar.hmr{at}ssss.gouv.qc.ca

We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.




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