- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.105.046110v1
172/2/1369 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Douville, J.
- Articles by Ramotar, D.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Douville, J.
- Articles by Ramotar, D.
Originally published as Genetics Published Articles Ahead of Print on December 1, 2005.
Genetics, Vol. 172, 1369-1372, February 2006, Copyright © 2006
doi:10.1534/genetics.105.046110
The Saccharomyces cerevisiae Phosphatase Activator RRD1 Is Required to Modulate Gene Expression in Response to Rapamycin Exposure
Julie Douville*,
Jocelyn David*,
Karine M. Lemieux
,
Luc Gaudreau and
Dindial Ramotar*,1
Département de Biologie, Université de Sherbrooke, Sherbrooke, Quebec J1K 2R1, Canada and the * University of Montreal, Maisonneuve-Rosemont Hospital, Guy-Bernier Research Centre, Montreal, Quebec H1T 2M4, Canada
1 Corresponding author: University of Montreal, Maisonneuve-Rosemont Hospital, Guy-Bernier Research Centre, 5415 de l'Assomption, Montreal, Quebec H1T 2M4, Canada.
E-mail: dramotar.hmr{at}ssss.gouv.qc.ca
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.
This article has been cited by other articles:
 |
|
 |
|
  M. Shimanuki, S.-Y. Chung, Y. Chikashige, Y. Kawasaki, L. Uehara, C. Tsutsumi, M. Hatanaka, Y. Hiraoka, K. Nagao, and M. Yanagida Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombe Genes Cells, May 1, 2007; 12(5): 677 - 692. [Abstract] [Full Text] [PDF]
|
|