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Originally published as Genetics Published Articles Ahead of Print on October 11, 2005.
Genetics, Vol. 172, 713-718, January 2006, Copyright © 2006
doi:10.1534/genetics.105.044065
Directional Positive Selection on an Allele of Arbitrary Dominance
Kosuke M. Teshima1 and Molly Przeworski
Department of Human Genetics, University of Chicago, Chicago, Illinois 60637
1 Corresponding author: Department of Human Genetics, University of Chicago, 920 E. 58th St., 505 CLSC, Chicago IL 60637.
E-mail: kteshima{at}uchicago.edu
Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.
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