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Genetics, Vol. 172, 569-577, January 2006, Copyright © 2006
doi:10.1534/genetics.105.049916
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* Department of Biological Sciences, Barnard College, Columbia University, New York, New York 10027,
Department of Agronomy, Plant Sciences Unit, University of Missouri 65211, Columbia, Missouri,
Plant Genetics Research Unit, USDA-ARS, Columbia, Missouri 65211 and
Department of Ecology and Evolution, University of California, Irvine, California 92697
1 Corresponding author: Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027.
E-mail: bmorton{at}barnard.edu
AT pressure. We also observe a significant CpG effect, or increase in transition rate at CpG sites. At the regional level we find that the strength of the CpG effect is correlated with regional A + T content, ranging from a 1.7-fold increase in transition rate in relatively G + C-rich regions to a 2.6-fold increase in A + T-rich regions. We also observe a relationship between locus A + T content and GC
AT pressure. This regional effect is in opposition to the influence of the two immediate neighbors in that GC
AT pressure increases with increasing locus A + T content but decreases with increasing flanking base A + T content and may represent a relationship between genome location and mutation bias. The data indicate multiple context effects on mutations, resulting in significant variation in mutation dynamics across the genome. This article has been cited by other articles:
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