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Originally published as Genetics Published Articles Ahead of Print on September 12, 2005.
Genetics, Vol. 172, 401-410, January 2006, Copyright © 2006
doi:10.1534/genetics.104.040196
Chromosome-Wise Dissection of the Genome of the Extremely Big Mouse Line DU6i
Marianna R. Bevova*,
Yurii S. Aulchenko
,
,
Soner Aksu
,
Ulla Renne* and
Gudrun A. Brockmann*,,1
* Research Institute for the Biology of Farm Animals, D-18196 Dummerstorf, Germany, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands, Institute of Cytology and Genetics, 630090 Novosibirsk, Russia and Institute for Animal Sciences, Humboldt-Universität zu Berlin, D-10115 Berlin, Germany
1 Corresponding author: Breeding Biology and Molecular Genetics, Institute for Animal Sciences, Humboldt-Universität zu Berlin, Invalidenstrasse 42, D-10115 Berlin, Germany.
E-mail: gudrun.brockmann{at}agrar.hu-berlin.de
The extreme high-body-weight-selected mouse line DU6i is a polygenic model for growth research, harboring many small-effect QTL. We dissected the genome of this line into 19 autosomes and the Y chromosome by the construction of a new panel of chromosome substitution strains (CSS). The DU6i chromosomes were transferred to a DBA/2 mice genetic background by marker-assisted recurrent backcrossing. Mitochondria and the X chromosome were of DBA/2 origin in the backcross. During the construction of these novel strains, >4000 animals were generated, phenotyped, and genotyped. Using these data, we studied the genetic control of variation in body weight and weight gain at 21, 42, and 63 days. The unique data set facilitated the analysis of chromosomal interaction with sex and parent-of-origin effects. All analyzed chromosomes affected body weight and weight gain either directly or in interaction with sex or parent of origin. The effects were age specific, with some chromosomes showing opposite effects at different stages of development.
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