help button home button Genetics J Neurosci
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on October 11, 2005.

Genetics, Vol. 172, 17-26, January 2006, Copyright © 2006
doi:10.1534/genetics.105.045922

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
genetics.105.045922v1
172/1/17    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, I.-N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, I.-N.

Lysis Timing and Bacteriophage Fitness

Ing-Nang Wang1

Department of Biological Sciences, State University of New York, Albany, New York 12222

1 Address for correspondence: Department of Biological Sciences, State University of New York, 1400 Washington Ave., Albany, NY 12222.
E-mail: ingnang{at}albany.edu

The effect of lysis timing on bacteriophage (phage) fitness has received little theoretical or experimental attention. Previously, the impact of lysis timing on phage fitness was studied using a theoretical model based on the marginal value theorem from the optimal foraging theory. An implicit conclusion of the model is that, for any combination of host quantity and quality, an optimal time to lyse the host would exist so that the phage fitness would be the highest. To test the prediction, an array of isogenic {lambda}-phages that differ only in their lysis times was constructed. For each phage strain, the lysis time, burst size, and fitness (growth rate) were determined. The result showed that there is a positive linear relationship between lysis time and burst size. Moreover, the strain with an intermediate lysis time has the highest fitness, indicating the existence of an optimal lysis time. A mathematical model is also constructed to describe the population dynamics of phage infection. Computer simulations using parameter values derived from phage {lambda}-infection also showed an optimal lysis time. However, both the optimum and the fitness are different from the experimental result. The evolution of phage lysis timing is discussed from the perspectives of multiple infection and life-history trait evolution.




This article has been cited by other articles:


Home page
 MicrobiologyHome page
Y. Zheng, D. K. Struck, C. A. Dankenbring, and R. Young
Evolutionary dominance of holin lysis systems derives from superior genetic malleability
Microbiology, June 1, 2008; 154(6): 1710 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
T. Park, D. K. Struck, C. A. Dankenbring, and R. Young
The Pinholin of Lambdoid Phage 21: Control of Lysis by Membrane Depolarization
J. Bacteriol., December 15, 2007; 189(24): 9135 - 9139.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Genetics Society of America.