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Originally published as Genetics Published Articles Ahead of Print on September 2, 2005.
Genetics, Vol. 171, 1779-1787, December 2005, Copyright © 2005
doi:10.1534/genetics.105.044800
An Integrated Genetic and Physical Map for the Malaria Vector Anopheles funestus
Charles S. Wondji*,1,
Richard H. Hunt
,
Patricia Pignatelli*,
Keith Steen*,
Maureen Coetzee
,
,
Nora Besansky**,
Neil Lobo**,
Frank H. Collins**,
Janet Hemingway* and
Hilary Ranson*
* Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom, National Institute for Communicable Diseases, Johannesburg, 2000 South Africa, ** Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, Medical Entomology, Division of Clinical Microbiology and Infectious Diseases, School of Pathology of the National Health Laboratory Service and University of the Witwatersrand, Johannesburg, 2000 South Africa and School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, 2050 South Africa
1 Corresponding author: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
E-mail: c.s.wondji{at}liverpool.ac.uk
We have constructed a genetic map of the major African malaria vector, Anopheles funestus, using genetic markers segregating in F2 progeny from crosses between two strains colonized from different field sites. Genotyping was performed on 174 progeny from three families using 33 microsatellite markers, a single RFLP, and 15 single nucleotide polymorphism (SNP) loci. Four linkage groups were resolved and these were anchored to chromosomes X and 2 and chromosomal arms 3R and 3L by comparison with a physical map of this species. Five markers were linked to the X chromosome, 16 markers to chromosome 2, and 10 and 11 markers to chromosomal arms 3R and 3L, respectively. This significantly increases the number of chromosomally defined genetic markers for this species and will facilitate the identification of genes controlling epidemiologically important traits such as resistance to insecticides or vector competence.
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