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Originally published as Genetics Published Articles Ahead of Print on September 2, 2005.
Genetics, Vol. 171, 1767-1777, December 2005, Copyright © 2005
doi:10.1534/genetics.105.048827
Two Distinct Domains in Drosophila melanogaster Telomeres
Harald Biessmann*,
Sudha Prasad
,
Valery F. Semeshin
,
Eugenia N. Andreyeva,
Quang Nguyen
,
Marika F. Walter* and
James M. Mason,1
* Developmental Biology Center, University of California, Irvine, California 92697, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Laboratory of Molecular Cytogenetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk 630090, Russia and Department of Biological Chemistry, University of California, Irvine, California 92697
1 Corresponding author: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, 111 Alexander Dr., Research Triangle Park, NC 27709-2233.
E-mail: masonj{at}niehs.nih.gov
Telomeres are generally considered heterochromatic. On the basis of DNA composition, the telomeric region of Drosophila melanogaster contains two distinct subdomains: a subtelomeric region of repetitive DNA, termed TAS, and a terminal array of retrotransposons, which perform the elongation function instead of telomerase. We have identified several P-element insertions into this retrotransposon array and compared expression levels of transgenes with similar integrations into TAS and euchromatic regions. In contrast to insertions in TAS, which are silenced, reporter genes in the terminal HeT-A, TAHRE, or TART retroelements did not exhibit repressed expression in comparison with the same transgene construct in euchromatin. These data, in combination with cytological studies, provide evidence that the subtelomeric TAS region exhibits features resembling heterochromatin, while the terminal retrotransposon array exhibits euchromatic characteristics.
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