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Originally published as Genetics Published Articles Ahead of Print on September 2, 2005.
Genetics, Vol. 171, 1729-1739, December 2005, Copyright © 2005
doi:10.1534/genetics.105.041947
Mechanisms of Genetic Exchange Within the Chromosomal Inversions of Drosophila pseudoobscura
Stephen W. Schaeffer*,1 and
Wyatt W. Anderson
* Department of Biology and Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park, PA 16802-5301 and Department of Genetics, University of Georgia, Athens, GA 30602
1 Corresponding author: Department of Biology, Pennsylvania State University, 208 Erwin W. Mueller Laboratories, University Park, PA 16802-5301.
E-mail: sws4{at}psu.edu
We have used the inversion system of Drosophila pseudoobscura to investigate how genetic flux occurs among the gene arrangements. The patterns of nucleotide polymorphism at seven loci were used to infer gene conversion events between pairs of different gene arrangements. We estimate that the average gene conversion tract length is 205 bp and that the average conversion rate is 3.4 x 10–6, which is 2 orders of magnitude greater than the mutation rate. We did not detect gene conversion events between all combinations of gene arrangements even though there was sufficient nucleotide variation for detection and sufficient opportunity for exchanges to occur. Genetic flux across the inverted chromosome resulted in higher levels of differentiation within 0.1 Mb of inversion breakpoints, but a slightly lower level of differentiation in central inverted regions. No gene conversion events were detected within 17 kb of an inversion breakpoint suggesting that the formation of double-strand breaks is reduced near rearrangement breakpoints in heterozygotes. At least one case where selection rather than proximity to an inversion breakpoint is responsible for reduction in polymorphism was identified.
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