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Originally published as Genetics Published Articles Ahead of Print on August 3, 2005.

Genetics, Vol. 171, 1437-1439, November 2005, Copyright © 2005
doi:10.1534/genetics.105.045930

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A Statistical Multiprobe Model for Analyzing cis and trans Genes in Genetical Genomics Experiments With Short-Oligonucleotide Arrays

Rudi Alberts*,1, Peter Terpstra*, Leonid V. Bystrykh{dagger}, Gerald de Haan{dagger} and Ritsert C. Jansen*

* Groningen Bioinformatics Centre (GBiC), Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, 9751 NN, Haren, The Netherlands and {dagger} Department of Cell Biology, Section of Stem Cell Biology, University Medical Centre Groningen, University of Groningen, Groningen, 9713 AV, The Netherlands

1 Corresponding author: Groningen Bioinformatics Centre, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands.
E-mail: r.alberts{at}rug.nl

Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating "true" differential mRNA expression from "ghost" effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.




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