- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.105.040782v1
171/3/1173 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Heifetz, E. M.
- Articles by Soller, M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Heifetz, E. M.
- Articles by Soller, M.
Originally published as Genetics Published Articles Ahead of Print on August 22, 2005.
Genetics, Vol. 171, 1173-1181, November 2005, Copyright © 2005
doi:10.1534/genetics.105.040782
Extent and Consistency Across Generations of Linkage Disequilibrium in Commercial Layer Chicken Breeding Populations
E. M. Heifetz*,
,1,
J. E. Fulton
,
N. O'Sullivan,
H. Zhao,
J. C. M. Dekkers and
M. Soller*,2
* Department of Genetics, Hebrew University, 91904 Jerusalem, Israel, Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011 and Hy-Line International, Dallas Center, Iowa 50063
2 Corresponding author: Department of Genetics, Hebrew University, 91904 Jerusalem, Israel.
E-mail: soller{at}vms.huji.ac.il
Recent studies report a surprisingly high degree of marker-to-marker linkage disequilibrium (LD) in ruminant livestock populations. This has important implications for QTL mapping and marker-assisted selection. This study evaluated LD between microsatellite markers in a number of breeding populations of layer chickens using the standardized chi-square (
2') measure. The results show appreciable LD among markers separated by up to 5 cM, decreasing rapidly with increased separation between markers. The LD within 5 cM was strongly conserved across generations and differed among chromosomal regions. Using marker-to-marker LD as an indication for marker-QTL LD, a genome scan of markers spaced 2 cM apart at moderate power would have good chances of uncovering most QTL segregating in these populations. However, of markers showing significant trait associations, only 57% are expected to be within 5 cM of the responsible QTL, and the remainder will be up to 20 cM away. Thus, high-resolution LD mapping of QTL will require dense marker genotyping across the region of interest to allow for interval mapping of the QTL.
This article has been cited by other articles:
 |
|
 |
|
  H. P. Xu, X. Shen, M. Zhou, C. L. Luo, L. Kang, Y. Liang, H. Zeng, Q. H. Nie, D. X. Zhang, and X. Q. Zhang The dopamine D2 receptor gene polymorphisms associated with chicken broodiness Poult. Sci., March 1, 2010; 89(3): 428 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. W. de Roos, B. J. Hayes, and M. E. Goddard Reliability of Genomic Predictions Across Multiple Populations Genetics, December 1, 2009; 183(4): 1545 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Janes, T. Ezaz, J. A. Marshall Graves, and S. V. Edwards Recombination and Nucleotide Diversity in the Sex Chromosomal Pseudoautosomal Region of the Emu, Dromaius novaehollandiae J. Hered., March 1, 2009; 100(2): 125 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Odegard, M. H. Yazdi, A. K. Sonesson, and T. H. E. Meuwissen Incorporating Desirable Genetic Characteristics From an Inferior Into a Superior Population Using Genomic Selection Genetics, February 1, 2009; 181(2): 737 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lipkin, K. Straus, R. T. Stein, A. Bagnato, F. Schiavini, L. Fontanesi, V. Russo, I. Medugorac, M. Foerster, J. Solkner, et al. Extensive Long-Range and Nonsyntenic Linkage Disequilibrium in Livestock Populations: Deconstruction of a Conundrum Genetics, February 1, 2009; 181(2): 691 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. W. de Roos, B. J. Hayes, R. J. Spelman, and M. E. Goddard Linkage Disequilibrium and Persistence of Phase in Holstein-Friesian, Jersey and Angus Cattle Genetics, July 1, 2008; 179(3): 1503 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Amaral, H.-J. Megens, R. P. M. A. Crooijmans, H. C. M. Heuven, and M. A. M. Groenen Linkage Disequilibrium Decay and Haplotype Block Structure in the Pig Genetics, May 1, 2008; 179(1): 569 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stapley, T. R. Birkhead, T. Burke, and J. Slate A Linkage Map of the Zebra Finch Taeniopygia guttata Provides New Insights Into Avian Genome Evolution Genetics, May 1, 2008; 179(1): 651 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Andreescu, S. Avendano, S. R. Brown, A. Hassen, S. J. Lamont, and J. C. M. Dekkers Linkage Disequilibrium in Related Breeding Lines of Chickens Genetics, December 1, 2007; 177(4): 2161 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Dodgson The Chicken Genome: Some Good News and Some Bad News Poult. Sci., July 1, 2007; 86(7): 1453 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Soller, S. Weigend, M. N. Romanov, J. C. M. Dekkers, and S. J. Lamont Strategies to Assess Structural Variation in the Chicken Genome and its Associations with Biodiversity and Biological Performance Poult. Sci., December 1, 2006; 85(12): 2061 - 2078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Backstrom, A. Qvarnstrom, L. Gustafsson, and H. Ellegren Levels of linkage disequilibrium in a wild bird population Biol Lett, September 22, 2006; 2(3): 435 - 438. [Abstract] [Full Text] [PDF]
|
|
|