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Originally published as Genetics Published Articles Ahead of Print on July 14, 2005.
Genetics, Vol. 171, 861-864, October 2005, Copyright © 2005
doi:10.1534/genetics.104.035774
Update on Estimation of Mutation Rates Using Data From Fluctuation Experiments
Qi Zheng1
Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M University System Health Science Center, Bryan, Texas 77802
1 Address for correspondence: Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M University System Health Science Center, 3000 Briarcrest, Suite 310, Bryan, Texas 77802.
E-mail: qzheng{at}srph.tamhsc.edu
This note discusses a minor mathematical error and a problematic mathematical assumption in Luria and Delbrück's (1943) classic article on fluctuation analysis. In addition to suggesting remedial measures, the note provides information on the latest development of techniques for estimating mutation rates using data from fluctuation experiments.
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