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Originally published as Genetics Published Articles Ahead of Print on July 14, 2005.
Genetics, Vol. 171, 845-847, October 2005, Copyright © 2005
doi:10.1534/genetics.105.047720
Drosophila ATM and Mre11 Are Essential for the G2/M Checkpoint Induced by Low-Dose Irradiation
Xiaolin Bi1, Min Gong1, Deepa Srikanta and Yikang S. Rong2
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
2 Corresponding author: National Institutes of Health, Bldg. 37, Room 6050, 37 Convent Dr., Bethesda, MD 20892.
E-mail: rongy{at}mail.nih.gov
Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G2/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase.
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