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Originally published as Genetics Published Articles Ahead of Print on July 14, 2005.
Genetics, Vol. 171, 835-838, October 2005, Copyright © 2005
doi:10.1534/genetics.105.044578
Discrepancies Between Recombination Frequencies and Physical Distances in Aspergillus nidulans: Implications for Gene Identification
Eduardo A. Espeso*,
Laura Cobeño* and
Herbert N. Arst, Jr.
,1
* Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Madrid 28040, Spain and Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom
1 Corresponding author: Department of Infectious Diseases, Imperial College London, Ducane Rd., London W12 0NN, United Kingdom.
E-mail: h.arst{at}imperial.ac.uk
A rapid route to gene molecular identification involves using recombination frequencies in locating mutational sequence changes. We describe a case where the recombination frequency is deceptively low, probably reflecting centromere proximity. Recombination frequencies are greatly reduced near the centromeres on the right arms of chromosomes III and IV of Aspergillus nidulans.
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