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Originally published as Genetics Published Articles Ahead of Print on July 5, 2005.
Genetics, Vol. 171, 829-833, October 2005, Copyright © 2005
doi:10.1534/genetics.105.046060
Transcriptional Compensation for Gene Loss Plays a Minor Role in Maintaining Genetic Robustness in Saccharomyces cerevisiae
Sharyl L. Wong and Frederick P. Roth1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
1 Corresponding author: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02115.
E-mail: fritz_roth{at}hms.harvard.edu
If a gene is mutated and its function lost, are compensatory genes upregulated? We investigated whether genes are transcriptionally upregulated when their synthetic sick or lethal (SSL) partners are lost. We identified several new examples; however, remarkably few SSL pairs exhibited this phenomenon, suggesting that transcriptional compensation by SSL partners is a rare mechanism for maintaining genetic robustness.
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