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Originally published as Genetics Published Articles Ahead of Print on June 18, 2005.
Genetics, Vol. 171, 825-827, October 2005, Copyright © 2005
doi:10.1534/genetics.105.045526
Intermediate Mutation Frequencies Favor Evolution of Multidrug Resistance in Escherichia coli
Erick Denamur*,
Olivier Tenaillon*,
Catherine Deschamps*,
,
David Skurnik,
Esthel Ronco
,
Jean Louis Gaillard,
Bertrand Picard,
Catherine Branger*, and
Ivan Matic
,1
* INSERM U722 and Université Paris 7, Paris, France, Laboratoires de Microbiologie, GHU Nord, AP-HP, Colombes, Paris, Bobigny, France, Laboratoire de Microbiologie, GHU Ouest, AP-HP, Garches, France and INSERM U571 and Université Paris 5, Paris, France
1 Corresponding author: INSERM U571 Faculté de Medecine-Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15, France.
E-mail: matic{at}necker.fr
In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.
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