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Originally published as Genetics Published Articles Ahead of Print on July 14, 2005.
Genetics, Vol. 171, 765-781, October 2005, Copyright © 2005
doi:10.1534/genetics.105.042093
Segmental Structure of the Brassica napus Genome Based on Comparative Analysis With Arabidopsis thaliana
Isobel A. P. Parkin*,1,
Sigrun M. Gulden*,
Andrew G. Sharpe*,
Lewis Lukens
,
Martin Trick
,
Thomas C. Osborn
and
Derek J. Lydiate*
* Saskatoon Research Centre, Agriculture and Agri-Food Canada, Saskatoon, Saskatchewan S7N 0X2, Canada, University of Guelph, Guelph, Ontario N1G 2W1, Canada, John Innes Centre, Norwich NR4 7UH, United Kingdom and Department of Agronomy, University of Wisconsin, Madison, Wisconsin 53706
1 Corresponding author: Saskatoon Research Centre, Agriculture and Agri-Food Canada, 107 Science Place, Saskatoon, SK S7N 0X2, Canada.
E-mail: parkini{at}agr.gc.ca
Over 1000 genetically linked RFLP loci in Brassica napus were mapped to homologous positions in the Arabidopsis genome on the basis of sequence similarity. Blocks of genetically linked loci in B. napus frequently corresponded to physically linked markers in Arabidopsis. This comparative analysis allowed the identification of a minimum of 21 conserved genomic units within the Arabidopsis genome, which can be duplicated and rearranged to generate the present-day B. napus genome. The conserved regions extended over lengths as great as 50 cM in the B. napus genetic map, equivalent to 
9 Mb of contiguous sequence in the Arabidopsis genome. There was also evidence for conservation of chromosome landmarks, particularly centromeric regions, between the two species. The observed segmental structure of the Brassica genome strongly suggests that the extant Brassica diploid species evolved from a hexaploid ancestor. The comparative map assists in exploiting the Arabidopsis genomic sequence for marker and candidate gene identification within the larger, intractable genomes of the Brassica polyploids.
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