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Originally published as Genetics Published Articles Ahead of Print on June 21, 2005.
Genetics, Vol. 171, 63-69, September 2005, Copyright © 2005
doi:10.1534/genetics.105.043869
Estimating the Time to the Whole-Genome Duplication and the Duration of Concerted Evolution via Gene Conversion in Yeast
Ryuichi P. Sugino*,
and
Hideki Innan*,1
* Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas 77030 and Laboratory of Crop Evolution, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
1 Corresponding author: Human Genetics Center, School of Public Health, University of Texas Health Science Center, 1200 Hermann Pressler, Houston, TX 77030.
E-mail: hideki.innan{at}uth.tmc.edu
A maximum-likelihood (ML) method is developed to estimate the duration of concerted evolution and the time to the whole-genome duplication (WGD) event in baker's yeast (Saccharomyces cerevisiae). The models with concerted evolution fit the data significantly better than the molecular clock model, indicating a crucial role of concerted evolution via gene conversion after gene duplication in yeast. Our ML estimate of the time to the WGD is nearly identical to the time to the speciation event between S. cerevisiae and Kluyveromyces waltii, suggesting that the WGD occurred in very early stages after speciation or the WGD might have been involved in the speciation event.
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