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Originally published as Genetics Published Articles Ahead of Print on June 18, 2005.
Genetics, Vol. 171, 403-406, September 2005, Copyright © 2005
doi:10.1534/genetics.105.045674
Smg1 Nonsense Mutations Do Not Abolish Nonsense-Mediated mRNA Decay in Drosophila melanogaster
Zhenzhong Chen*,
,
Katherine R. Smith*,
Philip Batterham*, and
Charles Robin*,1
* Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Melbourne, Victoria 3010, Australia and Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria 3010, Australia
1 Corresponding author: Genetics Department, University of Melbourne, Gate 12 Royal Parade, Melbourne, Victoria 3010, Australia.
E-mail: crobin{at}unimelb.edu.au
Smg1 is a key component of nonsense-mediated decay (NMD) in Caenorhabditis elegans and mammals. Here we report that two nonsense alleles of the ortholog of Smg1 do not affect NMD in Drosophila melanogaster.
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