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Originally published as Genetics Published Articles Ahead of Print on June 8, 2005.
Genetics, Vol. 171, 157-167, September 2005, Copyright © 2005
doi:10.1534/genetics.104.039610
Genome-Wide Analysis on Inbreeding Effects on Gene Expression in Drosophila melanogaster
Torsten Nygaard Kristensen*,
,1,
Peter Sørensen,
Mogens Kruhøffer
,
Kamilla Sofie Pedersen*, and
Volker Loeschcke*
* Aarhus Centre for Environmental Stress Research (ACES), Department of Ecology and Genetics, University of Aarhus, 8000 Aarhus C, Denmark, Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, 8830 Tjele, Denmark and Aarhus University Hospital, Molecular Diagnostic Laboratory, 8200 Aarhus N, Denmark
1 Corresponding author: Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, 8830 Tjele, Denmark.
E-mail: torsten.nygaard{at}agrsci.dk
The deleterious consequences of inbreeding, especially in the form of inbreeding depression, are well known. However, little is known about how inbreeding affects genome-wide gene expression. Here, we show that inbreeding changes transcription levels for a number of genes. Gene expression profiles of Drosophila melanogaster lines inbred to F 
0.67 at different rates changed relative to those of noninbred lines, but the rate of inbreeding did not significantly affect gene expression patterns. Genes being differentially expressed with inbreeding are disproportionately involved in metabolism and stress responses, suggesting that inbreeding acts like an environmental stress factor.
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