help button home button Genetics J Histo Cito
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on June 3, 2005.

Genetics, Vol. 170, 1913-1927, August 2005, Copyright © 2005
doi:10.1534/genetics.104.038208

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
genetics.104.038208v1
170/4/1913    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hall, S. E.
Right arrow Articles by Preuss, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hall, S. E.
Right arrow Articles by Preuss, D.

Differential Rates of Local and Global Homogenization in Centromere Satellites From Arabidopsis Relatives

Sarah E. Hall*,{dagger}, Song Luo*,{ddagger}, Anne E. Hall*,{ddagger} and Daphne Preuss*,{ddagger},1

* Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637
{dagger} Committee on Genetics, University of Chicago, Chicago, Illinois 60637
{ddagger} Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637

1 Corresponding author: 1103 E. 57th St., Chicago, IL 60615.
E-mail: dpreuss{at}midway.uchicago.edu

Higher eukaryotic centromeres contain thousands of satellite repeats organized into tandem arrays. As species diverge, new satellite variants are homogenized within and between chromosomes, yet the processes by which particular sequences are dispersed are poorly understood. Here, we isolated and analyzed centromere satellites in plants separated from Arabidopsis thaliana by 5–20 million years, uncovering more rapid satellite divergence compared to primate {alpha}-satellite repeats. We also found that satellites derived from the same genomic locus were more similar to each other than satellites derived from disparate genomic regions, indicating that new sequence alterations were homogenized more efficiently at a local, rather than global, level. Nonetheless, the presence of higher-order satellite arrays, similar to those identified in human centromeres, indicated limits to local homogenization and suggested that sequence polymorphisms may play important functional roles. In two species, we defined more extensive polymorphisms, identifying physically separated and highly distinct satellite types. Taken together, these data show that there is a balance between plant satellite homogenization and the persistence of satellite variants. This balance could ultimately generate sufficient sequence divergence to cause mating incompatibilities between plant species, while maintaining adequate conservation within a species for centromere activity.




This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
N. Mestrovic, P. Castagnone-Sereno, and M. Plohl
Interplay of Selective Pressure and Stochastic Events Directs Evolution of the MEL172 Satellite DNA Library in Root-Knot Nematodes
Mol. Biol. Evol., December 1, 2006; 23(12): 2316 - 2325.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
H.-R. Lee, P. Neumann, J. Macas, and J. Jiang
Transcription and Evolutionary Dynamics of the Centromeric Satellite Repeat CentO in Rice
Mol. Biol. Evol., December 1, 2006; 23(12): 2505 - 2520.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
A. E. Hall, G. C. Kettler, and D. Preuss
Dynamic evolution at pericentromeres
Genome Res., March 1, 2006; 16(3): 355 - 364.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Genetics Society of America.