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Originally published as Genetics Published Articles Ahead of Print on June 3, 2005.
Genetics, Vol. 170, 1913-1927, August 2005, Copyright © 2005
doi:10.1534/genetics.104.038208
Differential Rates of Local and Global Homogenization in Centromere Satellites From Arabidopsis Relatives
Sarah E. Hall*,
,
Song Luo*,
,
Anne E. Hall*, and
Daphne Preuss*,,1
* Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637
Committee on Genetics, University of Chicago, Chicago, Illinois 60637
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637
1 Corresponding author: 1103 E. 57th St., Chicago, IL 60615.
E-mail: dpreuss{at}midway.uchicago.edu
Higher eukaryotic centromeres contain thousands of satellite repeats organized into tandem arrays. As species diverge, new satellite variants are homogenized within and between chromosomes, yet the processes by which particular sequences are dispersed are poorly understood. Here, we isolated and analyzed centromere satellites in plants separated from Arabidopsis thaliana by 5–20 million years, uncovering more rapid satellite divergence compared to primate 
-satellite repeats. We also found that satellites derived from the same genomic locus were more similar to each other than satellites derived from disparate genomic regions, indicating that new sequence alterations were homogenized more efficiently at a local, rather than global, level. Nonetheless, the presence of higher-order satellite arrays, similar to those identified in human centromeres, indicated limits to local homogenization and suggested that sequence polymorphisms may play important functional roles. In two species, we defined more extensive polymorphisms, identifying physically separated and highly distinct satellite types. Taken together, these data show that there is a balance between plant satellite homogenization and the persistence of satellite variants. This balance could ultimately generate sufficient sequence divergence to cause mating incompatibilities between plant species, while maintaining adequate conservation within a species for centromere activity.
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