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Originally published as Genetics Published Articles Ahead of Print on May 23, 2005.
Genetics, Vol. 170, 1427-1430, July 2005, Copyright © 2005
doi:10.1534/genetics.105.040683
The Course of Malaria in Mice
Major Histocompatibility Complex (MHC) Effects, but No General MHC Heterozygote Advantage in Single-Strain Infections
Claus Wedekind*,
,1,
Mirjam Walker
,
,** and
Tom J. Little
* Zoological Institute, Division of Conservation Biology, University of Bern, 3012 Bern, Switzerland
Program for Evolutionary Dynamics and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138
Natural History Museum Bern, 3005 Bern, Switzerland
Institute of Zoo and Wildlife Biology, 10252 Berlin, Germany
** Harvard School of Public Health, Harvard University, Boston, Massachusetts 02115
School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, United Kingdom
1 Corresponding author: Department of Ecology and Evolution, Biology Bldg., University of Lausanne, 1015 Lausanne, Switzerland.
E-mail: claus.wedekind{at}unil.ch
A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, parasite strain, and host gender. However, the MHC heterozygotes did worse than expected from the average response of the homozygotes.
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