- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.039040v1
170/3/1189 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Lynn, D. J.
- Articles by Bradley, D. G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Lynn, D. J.
- Articles by Bradley, D. G.
Originally published as Genetics Published Articles Ahead of Print on March 31, 2005.
Genetics, Vol. 170, 1189-1196, July 2005, Copyright © 2005
doi:10.1534/genetics.104.039040
A Genomics Approach to the Detection of Positive Selection in Cattle:
Adaptive Evolution of the T-Cell and Natural Killer Cell-Surface Protein CD2
David J. Lynn, Abigail R. Freeman, Caitriona Murray and Daniel G. Bradley1
Department of Genetics, Smurfit Institute, Trinity College, Dublin 2, Ireland
1 Corresponding author: Department of Genetics, Smurfit Institute, Trinity College, Dublin 2, Ireland.
E-mail: dbradley{at}tcd.ie
The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an important domestic species. This analysis led to the identification of the T-cell and natural killer (NK) cell receptor cluster of differentiation 2 (CD2) as having a strong signal of selection. Further detailed investigation of CD2 revealed that this gene was subject to positive selection during the evolution of a number of mammalian lineages. Moreover, we show that selection has operated primarily on the extracellular domain of CD2 and discuss the implications of this for an important regulator of the adaptive immune response.
This article has been cited by other articles:
 |
|
 |
|
  W. Y. Low, H. L. Ng, C. J. Morton, M. W. Parker, P. Batterham, and C. Robin Molecular Evolution of Glutathione S-Transferases in the Genus Drosophila Genetics, November 1, 2007; 177(3): 1363 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Anisimova and Z. Yang Multiple Hypothesis Testing to Detect Lineages under Positive Selection that Affects Only a Few Sites Mol. Biol. Evol., May 1, 2007; 24(5): 1219 - 1228. [Abstract] [Full Text] [PDF]
|
|
|