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Originally published as Genetics Published Articles Ahead of Print on March 31, 2005.
Genetics, Vol. 170, 971-974, June 2005, Copyright © 2005
doi:10.1534/genetics.105.041277
Mutations in Snail Family Genes Enhance Craniosynostosis of Twist1 Haplo-insufficient Mice
Implications for Saethre-Chotzen Syndrome
Kathleen F. Oram and Thomas Gridley1
The Jackson Laboratory, Bar Harbor, Maine 04609
1 Corresponding author: The Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609.
E-mail: gridley{at}jax.org
In Drosophila, mutations in the Twist gene interact with mutations in the Snail gene. We show that the mouse Twist1 mutation interacts with Snai1 and Snai2 mutations to enhance aberrant cranial suture fusion, demonstrating that genetic interactions between genes of the Twist and Snail families have been conserved during evolution.
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