Originally published as Genetics Published Articles Ahead of Print on March 31, 2005.

Genetics, Vol. 170, 969-970, June 2005, Copyright © 2005
doi:10.1534/genetics.104.040410

On the Mutation Rate of Herpes Simplex Virus Type 1

John W. Drake*,1 and Charles B. C. Hwang{dagger}

* Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709-2233
{dagger} Department of Microbiology and Immunology, College of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210

1 Corresponding author: Laboratory of Molecular Genetics, Room E-344, National Institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, NC 27709-2233.
E-mail: drake{at}niehs.nih.gov

All seven DNA-based microbes for which carefully established mutation rates and mutational spectra were previously available displayed a genomic mutation rate in the neighborhood of 0.003 per chromosome replication. The pathogenic mammalian DNA virus herpes simplex type 1 has an estimated genomic mutation rate compatible with that value.




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