- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.103.024752v1
170/2/859 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Ball, R. D.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Ball, R. D.
Originally published as Genetics Published Articles Ahead of Print on March 21, 2005.
Genetics, Vol. 170, 859-873, June 2005, Copyright © 2005
doi:10.1534/genetics.103.024752
Experimental Designs for Reliable Detection of Linkage Disequilibrium in Unstructured Random Population Association Studies
Roderick D. Ball1
New Zealand Forest Research Institute, Rotorua, New Zealand
1 Address for correspondence: New Zealand Forest Research Institute, P.B. 3020, Rotorua, New Zealand.
E-mail: rod.ball{at}forestresearch.co.nz
A method is given for design of experiments to detect associations (linkage disequilibrium) in a random population between a marker and a quantitative trait locus (QTL), or gene, with a given strength of evidence, as defined by the Bayes factor. Using a version of the Bayes factor that can be linked to the value of an F-statistic with an existing deterministic power calculation makes it possible to rapidly evaluate a comprehensive range of scenarios, demonstrating the feasibility, or otherwise, of detecting genes of small effect. The Bayes factor is advocated for use in determining optimal strategies for selecting candidate genes for further testing or applications. The prospects for fine-scale mapping of QTL are reevaluated in this framework. We show that large sample sizes are needed to detect small-effect genes with a respectable-sized Bayes factor, and to have good power to detect a QTL allele at low frequency it is necessary to have a marker with similar allele frequency near the gene.
This article has been cited by other articles:
 |
|
 |
|
  S. Isobe, A. Nakaya, and S. Tabata Genotype Matrix Mapping: Searching for Quantitative Trait Loci Interactions in Genetic Variation in Complex Traits DNA Res, November 13, 2007; (2007) dsm020v1. [Abstract] [Full Text] [PDF]
|
|