- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.040022v1
170/2/645 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Estes, S.
- Articles by Phillips, P. C.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Estes, S.
- Articles by Phillips, P. C.
Originally published as Genetics Published Articles Ahead of Print on April 16, 2005.
Genetics, Vol. 170, 645-653, June 2005, Copyright © 2005
doi:10.1534/genetics.104.040022
Spontaneous Mutational Correlations for Life-History, Morphological and Behavioral Characters in Caenorhabditis elegans
Suzanne Estes*,1,
Beverly C. Ajie*,2,
Michael Lynch
and
Patrick C. Phillips*
* Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403
Department of Biology, Indiana University, Bloomington, Indiana 47405
1 Corresponding author: Department of Zoology, Oregon State University, Corvallis, OR 97331-2914.
E-mail: estessu{at}science.oregonstate.edu
The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines of Caenorhabditis elegans, each having independently experienced an average of 370 generations of spontaneous mutation accumulation. Bivariate relationships of mutational effects indicate the existence of extensive pleiotropy. We find that mutations may tend to produce manifold effects on suites of functionally related traits; however, our data do not support the idea of completely parcelated pleiotropy, in which functional units are separately affected by mutations. Positive net phenotypic and mutational correlations are common for life-history traits, with environmental correlations being comparatively smaller and of the same sign for most pairs of traits. Observed mutational correlations are shown to be higher than those produced by the chance accumulation of nonpleiotropic mutations in the same lines.
This article has been cited by other articles:
 |
|
 |
|
  A. D. Cutter, A. Dey, and R. L. Murray Evolution of the Caenorhabditis elegans Genome Mol. Biol. Evol., June 1, 2009; 26(6): 1199 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Ostrow, N. Phillips, A. Avalos, D. Blanton, A. Boggs, T. Keller, L. Levy, J. Rosenbloom, and C. F. Baer Mutational Bias for Body Size in Rhabditid Nematodes Genetics, July 1, 2007; 176(3): 1653 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Griswold, B. Logsdon, and R. Gomulkiewicz Neutral Evolution of Multiple Quantitative Characters: A Genealogical Approach Genetics, May 1, 2007; 176(1): 455 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Ajie, L. M. Pintor, J. Watters, J. L. Kerby, J. I. Hammond, and A. Sih A framework for determining the fitness consequences of antipredator behavior Behav. Ecol., January 1, 2007; 18(1): 267 - 270. [Full Text] [PDF]
|
|
|
|
|
|
C. F. Baer, N. Phillips, D. Ostrow, A. Avalos, D. Blanton, A. Boggs, T. Keller, L. Levy, and E. Mezerhane Cumulative Effects of Spontaneous Mutations for Fitness in Caenorhabditis: Role of Genotype, Environment and Stress Genetics, November 1, 2006; 174(3): 1387 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Ajie, S. Estes, M. Lynch, and P. C. Phillips Behavioral Degradation Under Mutation Accumulation in Caenorhabditis elegans Genetics, June 1, 2005; 170(2): 655 - 660. [Abstract] [Full Text] [PDF]
|
|