help button home button Genetics Mol Pharm
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Originally published as Genetics Published Articles Ahead of Print on March 31, 2005.

Genetics, Vol. 170, 581-590, June 2005, Copyright © 2005
doi:10.1534/genetics.104.040253

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
genetics.104.040253v1
170/2/581    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davis, L.
Right arrow Articles by Smith, G. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davis, L.
Right arrow Articles by Smith, G. R.

Dynein Promotes Achiasmate Segregation in Schizosaccharomyces pombe

Luther Davis and Gerald R. Smith1

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024

1 Corresponding author: Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., A1-162, P.O. Box 19024, Seattle, WA 98109-1024.
E-mail: gsmith{at}fhcrc.org

Most organisms use crossovers (chiasmata) to maintain physical connections between homologous chromosomes that ensure their proper segregation at the first meiotic division. The fission yeast Schizosaccharomyces pombe has a residual ability to segregate homologous chromosomes in the absence of meiotic recombination (achiasmate segregation). Using cytologically tagged chromosomes, we established a role for the microtubule motor dynein in meiotic chromosome segregation. Dhc1, the motor subunit of dynein, is required for chromosome segregation in both the presence and the absence of recombination. Dlc1, a member of the Tctex-1 dynein light-chain family, preferentially affects the segregation of achiasmate chromosomes. Dlc1 is the first identified protein, outside of Drosophila, that preferentially affects achiasmate chromosome segregation. We discuss possible roles of the dynein motor in this process.




This article has been cited by other articles:


Home page
 GeneticsHome page
S. E. Thomas and B. D. McKee
Meiotic Pairing and Disjunction of Mini-X Chromosomes in Drosophila Is Mediated by 240-bp rDNA Repeats and the Homolog Conjunction Proteins SNM and MNM
Genetics, October 1, 2007; 177(2): 785 - 799.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. Pradillo, E. Lopez, C. Romero, E. Sanchez-Moran, N. Cunado, and J. L. Santos
An Analysis of Univalent Segregation in Meiotic Mutants of Arabidopsis thaliana: A Possible Role for Synaptonemal Complex
Genetics, February 1, 2007; 175(2): 505 - 511.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. Davis and G. R. Smith
The Meiotic Bouquet Promotes Homolog Interactions and Restricts Ectopic Recombination in Schizosaccharomyces pombe
Genetics, September 1, 2006; 174(1): 167 - 177.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Yamashita and M. Yamamoto
Fission Yeast Num1p Is a Cortical Factor Anchoring Dynein and Is Essential for the Horse-Tail Nuclear Movement During Meiotic Prophase
Genetics, July 1, 2006; 173(3): 1187 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. Y. Lui, T. L. Peoples-Holst, J. Chang Mell, H.-Y. Wu, E. W. Dean, and S. M. Burgess
Analysis of Close Stable Homolog Juxtaposition During Meiosis in Mutants of Saccharomyces cerevisiae
Genetics, July 1, 2006; 173(3): 1207 - 1222.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Genetics Society of America.