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Originally published as Genetics Published Articles Ahead of Print on March 21, 2005.

Genetics, Vol. 170, 481-485, May 2005, Copyright © 2005
doi:10.1534/genetics.104.037333

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Intron Size and Exon Evolution in Drosophila

Gabriel Marais1, Pierre Nouvellet2, Peter D. Keightley and Brian Charlesworth3

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom

3 Corresponding author: Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Bldgs., W. Mains Rd., Edinburgh, EH9 3JT, United Kingdom.
E-mail: brian.charlesworth{at}ed.ac.uk

We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.




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