- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.034538v1
170/1/221 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Melnikova, L.
- Articles by Georgiev, P.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Melnikova, L.
- Articles by Georgiev, P.
Originally published as Genetics Published Articles Ahead of Print on March 21, 2005.
Genetics, Vol. 170, 221-235, May 2005, Copyright © 2005
doi:10.1534/genetics.104.034538
The Ku Protein Complex Is Involved in Length Regulation of Drosophila Telomeres
Larisa Melnikova*,
Harald Biessmann
and
Pavel Georgiev*,1
* Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia
Developmental Biology Center, University of California, Irvine, California 92697
1 Corresponding author: Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.
E-mail: georgiev_p{at}mail.ru
Chromosome ends in Drosophila melanogaster can be elongated either by terminal attachment of the telomere-specific retrotransposons HeT-A and TART or by terminal gene conversion. Here we show that a decrease in Ku70 or Ku80 gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion. Loss of Ku80 has more pronounced effects than loss of Ku70. However, lower Ku70 concentration reduces the stability of terminally deficient chromosomes. Our results suggest a role of the end-binding Ku complex in the accessibility and length regulation of Drosophila telomeres.
This article has been cited by other articles:
 |
|
 |
|
  G. D. Raffa, G. Siriaco, S. Cugusi, L. Ciapponi, G. Cenci, E. Wojcik, and M. Gatti The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection PNAS, February 17, 2009; 106(7): 2271 - 2276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Anderson, W. D. Gilliland, and C. H. Langley Molecular Population Genetics and Evolution of Drosophila Meiosis Genes Genetics, January 1, 2009; 181(1): 177 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Frydrychova, J. M. Mason, and T. K. Archer HP1 Is Distributed Within Distinct Chromatin Domains at Drosophila Telomeres Genetics, September 1, 2008; 180(1): 121 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Frydrychova, H. Biessmann, A. Y. Konev, M. D. Golubovsky, J. Johnson, T. K. Archer, and J. M. Mason Transcriptional Activity of the Telomeric Retrotransposon HeT-A in Drosophila melanogaster Is Stimulated as a Consequence of Subterminal Deficiencies at Homologous and Nonhomologous Telomeres Mol. Cell. Biol., July 1, 2007; 27(13): 4991 - 5001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Savitsky, D. Kwon, P. Georgiev, A. Kalmykova, and V. Gvozdev Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline Genes & Dev., February 1, 2006; 20(3): 345 - 354. [Abstract] [Full Text] [PDF]
|
|