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Originally published as Genetics Published Articles Ahead of Print on September 30, 2004.

Genetics, Vol. 170, 127-138, May 2005, Copyright © 2005
doi:10.1534/genetics.104.032516

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High-Resolution Mapping of the Drosophila Fourth Chromosome Using Site-Directed Terminal Deficiencies

Rui Sousa-Neves*,1, Tamas Lukacsovich*, Claudia Mieko Mizutani{dagger}, John Locke{ddagger}, Lynn Podemski{ddagger} and J. Lawrence Marsh*

* Department of Developmental and Cell Biology and the Developmental Biology Center, University of California, Irvine, California 92697
{dagger} Section of Cell and Developmental Biology, University of California, San Diego, California 92093-0349
{ddagger} Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada

1 Corresponding author: Department of Developmental and Cell Biology, Room 4444, McGaugh Hall, University of California, Irvine, CA 92697.
E-mail: nevesr{at}uci.edu

For more than 80 years, the euchromatic right arm of the Drosophila fourth chromosome (101F-102F) has been one of the least genetically accessible regions of the fly genome despite the fact that many important genes reside there. To improve the mapping of genes on the fourth chromosome, we describe a strategy to generate targeted deficiencies and we describe 13 deficiencies that subdivide the 300 kb between the cytological coordinates 102A6 and 102C1 into five discrete regions plus a 200-kb region from 102C1 to 102D6. Together these deficiencies substantially improve the mapping capabilities for mutant loci on the fourth chromosome.




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