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Originally published as Genetics Published Articles Ahead of Print on January 31, 2005.

Genetics, Vol. 169, 2151-2163, April 2005, Copyright © 2005
doi:10.1534/genetics.104.032631

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Flexibility in a Gene Network Affecting a Simple Behavior in Drosophila melanogaster

Bruno van Swinderen and Ralph J. Greenspan1

Neurosciences Institute, San Diego, California 92121

1 Corresponding author: Neurosciences Institute, 10640 John Jay Hopkins Dr., San Diego, CA 92121.
E-mail: greenspan{at}nsi.edu

Gene interactions are emerging as central to understanding the realization of any phenotype. To probe the flexibility of interactions in a defined gene network, we isolated a set of 16 interacting genes in Drosophila, on the basis of their alteration of a quantitative behavioral phenotype—the loss of coordination in a temperature-sensitive allele of Syntaxin1A. The interactions inter se of this set of genes were then assayed in the presence and in the absence of the original Syntaxin1A mutation to ask whether the relationships among the 16 genes remain stable or differ after a change in genetic context. The pattern of epistatic interactions that occurs within this set of variants is dramatically altered in the two different genetic contexts. The results imply considerable flexibility in the network interactions of genes.




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