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Originally published as Genetics Published Articles Ahead of Print on January 16, 2005.
Genetics, Vol. 169, 2035-2045, April 2005, Copyright © 2005
doi:10.1534/genetics.104.033381
The WD40 Repeat Protein Fritz Links Cytoskeletal Planar Polarity to Frizzled Subcellular Localization in the Drosophila Epidermis
Simon Collier*,
,1,
Haeryun Lee
,2,
Rosemary Burgess and
Paul Adler
* Department of Biological Sciences, Marshall University, Huntington, West Virginia 25755
School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
Department of Biology and Cancer Center, University of Virginia, Charlottesville, Virginia 22903
1 Corresponding author: Department of Biological Sciences, Marshall University, 1 John Marshall Dr., Huntington, WV 25755.
E-mail: simon.collier{at}marshall.edu
Much of our understanding of the genetic mechanisms that control planar cell polarity (PCP) in epithelia has derived from studies of the formation of polarized cell hairs during Drosophila wing development. The correct localization of an F-actin prehair to the distal vertex of the pupal wing cell has been shown to be dependent upon the polarized subcellular localization of Frizzled and other core PCP proteins. However, the core PCP proteins do not organize actin cytoskeletal polarity directly but require PCP effector proteins such as Fuzzy and Inturned to mediate this process. Here we describe the characterization of a new PCP effector gene, fritz, that encodes a novel but evolutionarily conserved coiled-coil WD40 protein. We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites.
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