- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.031948v1
169/3/1649 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Symonds, V. V.
- Articles by Lloyd, A. M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Symonds, V. V.
- Articles by Lloyd, A. M.
Originally published as Genetics Published Articles Ahead of Print on January 16, 2005.
Genetics, Vol. 169, 1649-1658, March 2005, Copyright © 2005
doi:10.1534/genetics.104.031948
Mapping Quantitative Trait Loci in Multiple Populations of Arabidopsis thaliana Identifies Natural Allelic Variation for Trichome Density
V. Vaughan Symonds*,1,
A. Veronica Godoy*,2,
Teresa Alconada
,
Javier F. Botto,
Thomas E. Juenger
,
Jorge J. Casal and
Alan M. Lloyd*
* Section of Molecular, Cell and Developmental Biology, Institute for Cellular and Molecular Biology
Section of Integrative Biology, University of Texas, Austin, Texas 78712
IFEVA, Universidad de Buenos Aires, 1417-Buenos Aires, Argentina
1 Corresponding author: Section of Molecular, Cell and Developmental Biology, University of Texas, 2500 Speedway, MBB 1.448b, Austin, TX 78712.
E-mail: vsymonds{at}mail.utexas.edu
The majority of biological traits are genetically complex. Mapping the quantitative trait loci (QTL) that determine these phenotypes is a powerful means for estimating many parameters of the genetic architecture for a trait and potentially identifying the genes responsible for natural variation. Typically, such experiments are conducted in a single mapping population and, therefore, have only the potential to reveal genomic regions that are polymorphic between the progenitors of the population. What remains unclear is how well the QTL identified in any one mapping experiment characterize the genetics that underlie natural variation in traits. Here we provide QTL mapping data for trichome density from four recombinant inbred mapping populations of Arabidopsis thaliana. By aligning the linkage maps for these four populations onto a common physical map, the results from each experiment were directly compared. Seven of the nine QTL identified are population specific while two were mapped in all four populations. Our results show that many lineage-specific alleles that either increase or decrease trichome density persist in natural populations and that most of this genetic variation is additive. More generally, these findings suggest that the use of multiple populations holds great promise for better understanding the genetic architecture of natural variation.
This article has been cited by other articles:
 |
|
 |
|
  H. C. Rowe, B. G. Hansen, B. A. Halkier, and D. J. Kliebenstein Biochemical Networks and Epistasis Shape the Arabidopsis thaliana Metabolome PLANT CELL, May 1, 2008; 20(5): 1199 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Simon, O. Loudet, S. Durand, A. Berard, D. Brunel, F.-X. Sennesal, M. Durand-Tardif, G. Pelletier, and C. Camilleri Quantitative Trait Loci Mapping in Five New Large Recombinant Inbred Line Populations of Arabidopsis thaliana Genotyped With Consensus Single-Nucleotide Polymorphism Markers Genetics, April 1, 2008; 178(4): 2253 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Calenge, V. Saliba-Colombani, S. Mahieu, O. Loudet, F. Daniel-Vedele, and A. Krapp Natural Variation for Carbohydrate Content in Arabidopsis. Interaction with Complex Traits Dissected by Quantitative Genetics Plant Physiology, August 1, 2006; 141(4): 1630 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Heidel, M. J. Clauss, J. Kroymann, O. Savolainen, and T. Mitchell-Olds Natural Variation in MAM Within and Between Populations of Arabidopsis lyrata Determines Glucosinolate Phenotype Genetics, July 1, 2006; 173(3): 1629 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. El-Lithy, L. Bentsink, C. J. Hanhart, G. J. Ruys, D. Rovito, J. L. M. Broekhof, H. J. A. van der Poel, M. J. T. van Eijk, D. Vreugdenhil, and M. Koornneef New Arabidopsis Recombinant Inbred Line Populations Genotyped Using SNPWave and Their Use for Mapping Flowering-Time Quantitative Trait Loci Genetics, March 1, 2006; 172(3): 1867 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Shimizu and M. D. Purugganan Evolutionary and Ecological Genomics of Arabidopsis Plant Physiology, June 1, 2005; 138(2): 578 - 584. [Full Text] [PDF]
|
|