- THIS ARTICLE
- Full Text
- Full Text (PDF)
- Data Supplement
-
All Versions of this Article:
genetics.104.035303v1
169/3/1509 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Stump, A. D.
- Articles by Besansky, N. J.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Stump, A. D.
- Articles by Besansky, N. J.
Originally published as Genetics Published Articles Ahead of Print on January 16, 2005.
Genetics, Vol. 169, 1509-1519, March 2005, Copyright © 2005
doi:10.1534/genetics.104.035303
Sex-Linked Differentiation Between Incipient Species of Anopheles gambiae
Aram D. Stump*,
Jennifer A. Shoener*,
Carlo Costantini
,
,
N'Fale Sagnon and
Nora J. Besansky*,1
* Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556
Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou 01, Burkina Faso
Dipartimento di Scienze di Sanità Pubblica, Università degli Studi di Roma "La Sapienza," 00185 Rome, Italy
1 Corresponding author: Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Science Center, Notre Dame, IN 46556-0369.
E-mail: besansky.1{at}nd.edu
Emerging species within the primary malaria vector Anopheles gambiae show different ecological preferences and significant prezygotic reproductive isolation. They are defined by fixed sequence differences in X-linked rDNA, but most previous studies have failed to detect large and significant differentiation between these taxa elsewhere in the genome, except at two other loci on the X chromosome near the rDNA locus. Hypothesizing that this pericentromeric region of the X chromosome may be accumulating differences faster than other regions of the genome, we explored the pattern and extent of differentiation between A. gambiae incipient species and a sibling species, A. arabiensis, from Burkina Faso, West Africa, at 17 microsatellite loci spanning the X chromosome. Interspecific differentiation was large and significant across the entire X chromosome. Among A. gambiae incipient species, we found some of the highest levels of differentiation recorded in a large region including eight independent loci near the centromere of the X chromosome. Outside of this region, no significant differentiation was detected. This pattern suggests that selection is playing a role in the emergence of A. gambiae incipient species. This process, associated with efficient exploitation of anthropogenic modifications to the environment, has public health implications as it fosters the spread of malaria transmission both spatially and temporally.
This article has been cited by other articles:
 |
|
 |
|
  C. A. Machado, T. S. Haselkorn, and M. A. F. Noor Evaluation of the Genomic Extent of Effects of Fixed Inversion Differences on Intraspecific Variation and Interspecific Gene Flow in Drosophila pseudoobscura and D. persimilis Genetics, March 1, 2007; 175(3): 1289 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. WHITE, F. SANTOLAMAZZA, L. KAMAU, M. POMBI, O. GRUSHKO, K. MOULINE, C. BRENGUES, W. GUELBEOGO, M. COULIBALY, J. K. KAYONDO, et al. MOLECULAR KARYOTYPING OF THE 2LA INVERSION IN ANOPHELES GAMBIAE Am J Trop Med Hyg, February 1, 2007; 76(2): 334 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Yawson, D. Weetman, M. D. Wilson, and M. J. Donnelly Ecological Zones Rather Than Molecular Forms Predict Genetic Differentiation in the Malaria Vector Anopheles gambiae s.s. in Ghana Genetics, February 1, 2007; 175(2): 751 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Slotman, L. J. Reimer, T. Thiemann, G. Dolo, E. Fondjo, and G. C. Lanzaro Reduced Recombination Rate and Genetic Differentiation Between the M and S Forms of Anopheles gambiae s.s. Genetics, December 1, 2006; 174(4): 2081 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. POMBI, A. D. STUMP, A. D. TORRE, and N. J. BESANSKY VARIATION IN RECOMBINATION RATE ACROSS THE X CHROMOSOME OF ANOPHELES GAMBIAE Am J Trop Med Hyg, November 1, 2006; 75(5): 901 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Michel, O. Grushko, W. M. Guelbeogo, N. F. Lobo, N. Sagnon, C. Costantini, and N. J. Besansky Divergence With Gene Flow in Anopheles funestus From the Sudan Savanna of Burkina Faso, West Africa Genetics, July 1, 2006; 173(3): 1389 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. SLOTMAN, M. M. MENDEZ, A. D. TORRE, G. DOLO, Y. T. TOURE, and A. CACCONE GENETIC DIFFERENTIATION BETWEEN THE BAMAKO AND SAVANNA CHROMOSOMAL FORMS OF ANOPHELES GAMBIAE AS INDICATED BY AMPLIFIED FRAGMENT LENGTH POLYMORPHISM ANALYSIS Am J Trop Med Hyg, April 1, 2006; 74(4): 641 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Stump, M. C. Fitzpatrick, N. F. Lobo, S. Traore, N. Sagnon, C. Costantini, F. H. Collins, and N. J. Besansky Centromere-proximal differentiation and speciation in Anopheles gambiae PNAS, November 1, 2005; 102(44): 15930 - 15935. [Abstract] [Full Text] [PDF]
|
|