- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.104.031492v1
169/2/855 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Singer, J. B.
- Articles by Lander, E. S.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Singer, J. B.
- Articles by Lander, E. S.
Originally published as Genetics Published Articles Ahead of Print on September 15, 2004.
Genetics, Vol. 169, 855-862, February 2005, Copyright © 2005
doi:10.1534/genetics.104.031492
Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice
Jonathan B. Singer*,
,1,
Annie E. Hill
,
Joseph H. Nadeau,
and
Eric S. Lander*,
* Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
Center for Computational Genomics and Systems Biology, Case Western Reserve University, Cleveland, Ohio 44106
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142
1 Corresponding author: Clinical Pharmacogenetics, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave., Cambridge, MA 02139.
E-mail: jonathan.singer{at}pharma.novartis.com
Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity.
This article has been cited by other articles:
 |
|
 |
|
  S. Gregorova, P. Divina, R. Storchova, Z. Trachtulec, V. Fotopulosova, K. L. Svenson, L. R. Donahue, B. Paigen, and J. Forejt Mouse consomic strains: Exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies Genome Res., March 1, 2008; 18(3): 509 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takada, A. Mita, A. Maeno, T. Sakai, H. Shitara, Y. Kikkawa, K. Moriwaki, H. Yonekawa, and T. Shiroishi Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits Genome Res., March 1, 2008; 18(3): 500 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Thifault, S. Ondrej, Y. Sun, A. Fortin, E. Skamene, R. Lalonde, J. Tremblay, and P. Hamet Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes Hum. Mol. Genet., February 1, 2008; 17(3): 331 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Mattson, M. R. Dwinell, A. S. Greene, A. E. Kwitek, R. J. Roman, A. W. Cowley Jr., and H. J. Jacob Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1905 - F1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Knight, C. E. Pennell, S. L. Adamson, and S. J. Lye The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy J. Physiol., June 1, 2007; 581(2): 873 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Knight, C. E. Pennell, R. Shah, and S. J. Lye Strain Differences in the Impact of Dietary Restriction on Fetal Growth and Pregnancy in Mice Reproductive Sciences, January 1, 2007; 14(1): 81 - 90. [Abstract] [PDF]
|
|
|
|
 |
|
 I. M. Stylianou, S.-W. Tsaih, K. DiPetrillo, N. Ishimori, R. Li, B. Paigen, and G. Churchill Complex Genetic Architecture Revealed by Analysis of High-Density Lipoprotein Cholesterol in Chromosome Substitution Strains and F2 Crosses Genetics, October 1, 2006; 174(2): 999 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mott Finding the molecular basis of complex genetic variation in humans and mice Phil Trans R Soc B, March 29, 2006; 361(1467): 393 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Petryshen, A. Kirby, R. P. Hammer Jr., S. Purcell, S. B. O'Leary, J. B. Singer, A. E. Hill, J. H. Nadeau, M. J. Daly, and P. Sklar Two Quantitative Trait Loci for Prepulse Inhibition of Startle Identified on Mouse Chromosome 16 Using Chromosome Substitution Strains Genetics, December 1, 2005; 171(4): 1895 - 1904. [Abstract] [Full Text] [PDF]
|
|