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Originally published as Genetics Published Articles Ahead of Print on November 15, 2004.
Genetics, Vol. 169, 1133-1146, February 2005, Copyright © 2005
doi:10.1534/genetics.104.035212
The Genomes of Recombinant Inbred Lines
Karl W. Broman1
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205
1 Address for correspondence: Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205-2179.
E-mail: kbroman{at}jhsph.edu
Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a valuable community resource. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We extend the work of Haldane and Waddington on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiple-strain RILs as a function of the level of crossover interference in meiosis.
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