| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Genetics, Vol. 169, 1105-1115, February 2005, Copyright © 2005
doi:10.1534/genetics.104.030338
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||


* Department of Molecular Evolution, Uppsala University EBC, SE-75236 Uppsala, Sweden
Microbiology and Tumour Biology Center, Karolinska Institute and Department of Bacteriology, Swedish Institute for Infectious Disease Control, SE-171 82, Solna, Sweden
Microbiology Section/DBS, University of California, Davis, California 95616
1 Corresponding author: Department of Molecular Evolution, Uppsala University EBC, Norbyvägen 18C, SE-75236 Uppsala, Sweden.
E-mail: otto.berg{at}ebc.uu.se
20 generations of growth. This work examines the proposed amplification model from a theoretical point of view, formalizing it into a mathematical framework and using this to determine what would be required for the process to occur within the specified period. The analysis assumes no stress-induced change in mutation rate and describes only the growth improvement occurring during the process of amplification and subsequent elimination of excess mutant lac copies. The dynamics of the system are described using Monte Carlo simulations and numerical integration of the deterministic equations governing the system. The results imply that the amplification model can account for the behavior of the system using biologically reasonable parameter values and thus can, in principle, explain Cairnsian adaptive mutation. This article has been cited by other articles:
![]() |
B. Nystedt, A. C. Frank, M. Thollesson, and S. G. E. Andersson Diversifying Selection and Concerted Evolution of a Type IV Secretion System in Bartonella Mol. Biol. Evol., February 1, 2008; 25(2): 287 - 300. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Stumpf, A. R. Poteete, and P. L. Foster Amplification of lac Cannot Account for Adaptive Mutation to Lac+ in Escherichia coli J. Bacteriol., March 15, 2007; 189(6): 2291 - 2299. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Kugelberg, E. Kofoid, A. B. Reams, D. I. Andersson, and J. R. Roth Multiple pathways of selected gene amplification during adaptive mutation PNAS, November 14, 2006; 103(46): 17319 - 17324. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |